PORTFOLIO / FEATURED / Polycystic kidney disease

DESCRIPTION
  • Title
  • Tools
  • Audience
  • Format
  • Supervisors
  • Purpose
  • Highlights
Autosomal dominant polycystic kidney disease
Graphite, Adobe Photoshop CS4, Adobe Illustrator CS4
Educated lay-audience
Print
Prof. S. Wall1, Prof. D. Mazierski1 | Content experts: Dr. E. Hsieh2, Dr. J. Wong3
This conceptual illustration is intended for a double-page spread in a popular science magazine, such as Scientific American. It aims to capture attention and interest while delivering key facts about autosomal dominant polycystic kidney disease. The goals of this project included developing a methodology for depicting temporal events at multiple scales (gross, tissue, and cellular), researching and synthesizing scientific content, and rendering complex scenes using Photoshop.
This illustration received an Award of Merit in the Student Instructional Color category at the 66th Annual Meeting of the Association of Medical Illustrators
1Biomedical Communications, University of Toronto 2Department of Pathology, Sunnybrook Health Sciences Centre; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto 3Department of Anatomic Pathology, Sunnybrook Health Sciences Center
ADDITIONAL IMAGES

Tissue landscape study

I used this illustration to explore normal renal microarchitecture in greater depth. I wanted to create a very dramatic and dynamic composition using a forest analogy with nephron "trees". Scanning electron images and histological slides were used as references. (Graphite)


Tissue cube study

This illustration was created by constructing a 3D version of histological slides. The progression of ADPKD is depicted from right to left. (Graphite)

PROCESS

Sketch process

I usually create my initial sketches and final line art with traditional media.


Rendering process

I decided on this colour palette in the end because it seemed most appropriate for a pathological illustration.

REFERENCES
Carone, F.A., R. Bacallao, and Y.S. Kanwar. 1996. Pathogenesis of polycystic kidney disease: basement membrane and extracellular matrix. In: Watson, M.L. and V.E. Torres (Eds.). Polycystic Kidney Disease. New York: Oxford Medical Publications, pp. 111-124.
Evan, E.P. and JA McAteer. 1990. Cyst cells and cyst walls. In: Gardner, K.D. and J. Bernstein (Eds.). The Cystic Kidney. Boston: Kluwer Academic Publishers, pp. pp. 21-42.
Gabow, P.A. 1990. Autosomal Dominant Polycystic Kidney Disease. In: Gardner, K.D. and J. Bernstein (Eds.). The Cystic Kidney. Boston: Kluwer Academic Publishers, pp. 295-326.
Goldman, S.M. and D.S. Hartman. 1989. Autosomal Dominant Polycystic Kidney Disease. In: Hartman, D.S. 1989. Renal Cystic Disease. Toronto: W.B. Saunders Company, pp. 88-90.
Merck Manual, The. Autosomal Dominant Polycystic Kidney Disease (ADPKD), http://www.merck.com.
Torres, V.E. 1990. Systemic manifestations of renal cystic disease. In: Gardner, K.D. and J. Bernstein (Eds.). The Cystic Kidney. Boston: Kluwer Academic Publishers, pp. 207-245.
Wilson, P.D. 1996. Pathogenesis of polycystic kidney disease: altered cell function. In: Watson, M.L. and V.E. Torres (Eds.). Polycystic Kidney Disease. New York: Oxford Medical Publications, pp. 125-163.
Additional visual references
Cormack, D.H. 1993. Essential Histology. Philadelphia: J.B. Lippincott Company, pp. 324-325.
Kessel, R.G. and R.H. Kardon. 1979. Tissues and organs: A text-atlas of scanning electron microscopy. San Francisco: W.H. Freeman, pp. 224-225, 234.
Krstic, R.V. 1994. Human Microscopic Anatomy: An Atlas for Students of Medicine and Biology. New York: Springer-Verlag, pp.298-303, 322-323, 326-327
Ross, M.H., E.J. Reith, and L.J. Romrell.1989. Histology: A Text and Atlas (2nd ed.). Baltimore: Williams & Wilkins, pp. 552-557.
Standring, S (Ed.). 2005. Gray's Anatomy (39th ed.). Toronto: Elsevier Churchill Livingstone, pp. 1278-1279.
Wallace, D.P. and G. Reif. PKD tissue repository and biomaterials core facility for the Kansas interdisciplinary center for PKD research. KU Medical Center, The University of Kansas, http://www2.kumc.edu/ki/wallace.htm